The 34-year-old singer - who has nine-month-old son Bear with partner Liam Payne - thinks the 'Keeping Up With the Kardashians' star will make a great mother and she sent her well-wishes that the 33-year-old beauty has a ''happy and healthy'' pregnancy.
After Khloe announced she and boyfriend Tristan Thompson are expecting a baby on Instagram, Cheryl commented: ''Khloeeee!!! such amazing news. I could not be happier for you. You gorgeous soul!
''You are about to have the best, most precious time of your life. And you truly deserve it. Congratulations Mommy. Wishing you a happy healthy pregnancy and what a wonderful way to start a new year. (sic)''
Bella Hadid claimed Khloe's happy news had left her in tears.
She wrote: ''I am completely in tears Khlo, I'm so happy for you. You are going to be the best mama.''
'Stranger Things' star Millie Bobbie Brown, who is a 'Keeping Up With the Kardashians' fan also sent her congratulations.
She replied to Khloe's post: ''Omg absolutely amazing! congrats!''
Model Adrienne Bailon - who previously dated Khloe's sister Rob - thinks her friend will make ''the greatest mommy''.
She gushed: ''SCREAMING!! CONGRATULATIONS. I'm so BEYOND HAPPY for you... You are going to make the greatest, most giving, loving, nurturing, kind, fun & fly mommy! Ahhhh so happy for you.''
While the 'Revenge Body' star's famous family haven't directly spoken out about her pregnancy news, her mother Kris Jenner commented with a string of love heart emojis, while her half-sister Kendall Jenner also shared similar icons.
Tristan, 26, shared a loving message on Khloe's post.
He wrote: ''My love, thank you for [allowing] me to be a part of your journey in life and allowing to share this moment with you this is something [I'll] always cherish. Girl you look better now.
''My love, Thank you for allowing me to be apart [sic] of your journey and entering your life that day at the bel air hotel. One of the best moments of my life.
''I'm soo happy to be on this journey together with you and creating this angel from the man above. Everyday [sic] I give thanks to him for bringing us together. I love you soo much and I know our little angel feels the love we share together and will know that mommy and daddy loves them unconditional and forever and ever amen (sic)''
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