David Spade has donated $100,000 to a mental health charity.

The 53-year-old actor has given the money to the National Alliance on Mental Illness (NAMI) and urged those struggling to reach out for help and support, following the recent suicide of his sister-in-law, designer Kate Spade.

He said: ''More people suffer from mental health issues than we may realise but no one should ever feel ashamed to reach out for support.

''If you or anyone you know is in need of help or guidance please contact the national suicide prevention hotline at 800-273-8255 or go to nami.org to learn more and help those who may be in need.''

NAMI is the largest grassroots mental health organisation in the US and is dedicated to building better lives for the millions affected through support groups and educational programmes.

The 'Grown Ups' actor previously used his Instagram account to share a touching tribute to his late sister-in-law and admitted he still ''couldn't believe'' she'd passed away.

Alongside a photograph of himself and Kate - who was married to his brother Andy Spade - at a family gathering over the festive period, he wrote: ''Fuzzy picture but i love it. Kate and I during Christmas family photos. We had so much fun that day. She was so sharp and quick on her feet. She could make me laugh so hard. I still cant believe it. Its a rough world out there people, try to hang on. (sic)''

Meanwhile, David's brother, Andy recently paid a touching tribute to his late wife on behalf of himself and their 13-year-old daughter Bea.

Andy - who was living apart from Kate at the time of her death - said: ''Kate was the most beautiful woman in the world. She was the kindest person I've ever known and my best friend for 35 years. My daughter and I are devastated by her loss, and can't even begin to fathom life without her. We are deeply heartbroken and miss her already.

''Kate suffered from depression and anxiety for many years. She was actively seeking help and working closely with her doctors to treat her disease, one that takes far too many lives. We were in touch with her the night before and she sounded happy. There was no indication and no warning that she would do this. It was a complete shock. And it clearly wasn't her. There were personal demons she was battling...

''My main concern is Bea and protecting her privacy as she deals with the unimaginable grief of losing her mother. Kate loved Bea so very much.''