The 47-year-old producer - whose mother Joan Rivers was at the helm of the E! show before her tragic death - is to take on the hosting duties and returning panelist Giuliana couldn't be more thrilled.
She gushed to Us Weekly magazine: ''I think it'll be something different. She's not trying to be someone else, so she's just going to try to just bring her own unique personality to the table...
''I adore Melissa. I've known Melissa forever, we talk all the time, we text all the time. No one knows the show as well as Melissa. I think it's an exciting time for Fashion Police.
''I like that there's a familiarity there, and we all know each other so well, it's a lot harder to welcome a new person in because you have to get to know them and their timing.''
Melissa's new appointment was confirmed by Jeff Olde, the executive vice president of programming and development for E!.
He said: ''As an executive producer since the beginning, Melissa helped shape 'Fashion Police' into an iconic TV series that couples fashion with comedy.
''We are pleased to now also feature Melissa in front of the 'Fashion Police' cameras, as she joins returning panelists Giuliana and Brad. And with the added flavour of rotating panelists, the show will deliver fresh, different and unpredictable fashion reviews with each new episode.''
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Watch three incredible live performances from Discovr.TV.
Don't miss the K-pop titans' return to Europe.
Listen to Alex Bayly performing 'Animal'.
Two weeks ahead of Independent Venue Week, Dry Cleaning made 'Britain's Best Small Venue 2015' (NME) the second port of call on their 2020 tour.
'Leave Home' was released on this day (January 10th) in 1977.
For their last gig of the year, The Libertines came back to their adopted hometown of Margate to finish off their latest tour.