The movie star will make his first public appearance following his divorce settlement from Amber Heard when he accepts the inaugural Rhonda's Kiss Healing and Hope Award in Los Angeles on 3 November (16).

The bash at the El Rey Theatre on 3 November (16) will also feature a performance by rockers Weezer.

Proceeds from the event will benefit the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute.

"Cancer affects many lives and this year it was my family's turn," Depp said in a statement. "The team at Cedars-Sinai works tirelessly to help people in their darkest moments. Their work is invaluable to all of us, and I will support any opportunity to help shine a light on the cause through Rhonda's Kiss."

In May, just days before Heard filed for divorce from Depp, the Pirates of the Caribbean star's mother died after battling a long illness. She was 81.

"The contributions Johnny has continually made in honour of his mother have been instrumental in helping us to develop the kind of research we need to move the needle forward in the fight against lung cancer," a spokesman for the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute states. "He has made regular visits."