The 'Green Light' hitmaker - who made her return to the music scene last year - secured nominations in the Best International Solo Artist and Best Live Artist categories as well as a nod for Best Album for 'Melodrama' and Best Track for 'Green Light'.
Lorde will go head to head with Charli to battle it out for the Best Track award whilst the brunette singer also got a nod in Best Video for 'Boys', Best Mixtape for 'Pop 2' and Best British Solo Artist at the ceremony, which takes place at London's O2 Academy Brixton on February 14.
Dua Lipa received three nods - one in the Best British Solo Artist category and two nominations for 'New Rules' for Best Track and Best Video.
Alt-J, Kasabian, Wolf Alice, The 1975, The xx and Bastille will battle it out for Best British Band whilst Haim, The National, Foo Fighters, The Killers, Paramore and Migos received a nod in the Best International Band category.
Kasabian, Stormzy, Royal Blood, LCD Soundsystem and Liam Gallagher will go head to head with Lorde to be named Best Live Act.
After the tragic events of the Manchester terrorist attack, the tribute concert organised by Ariana Grande, One Love Manchester, has been nominated for Music Moment of the Year alongside The Killers' surprise Glastonbury set, Lady Gaga at the Super Bowl, Chester Bennington's tribute concert, Grime4Corbyn and Noel Gallagher playing 'Don't Look Back In Anger' at the re-opened Manchester Arena.
Ariana Grande's determination to return to Manchester after the devastating terror attack earned her a nod in the Hero of the Year category whilst actress Rose McGowan - who was one of the first people who spoke out to accuse Harvey Weinstein of sexual misconduct - also received a nod.
Liam Gallagher has already been confirmed to receive the Godlike Genius award at the ceremony at the O2 Academy Brixton, London on February 14.
Voting for winners is now open at awards.nme.com.
What's new in the music world this week?
'Sounds of Silence' was released on this day (January 17th) in 1966.
Listen to Alex Bayly performing 'Animal'.
Two weeks ahead of Independent Venue Week, Dry Cleaning made 'Britain's Best Small Venue 2015' (NME) the second port of call on their 2020 tour.
'Leave Home' was released on this day (January 10th) in 1977.
For their last gig of the year, The Libertines came back to their adopted hometown of Margate to finish off their latest tour.
Celebrating the birthday of David Bowie with his most legendary songs.