The One Direction bandmates will play solo sets at the event at Manchester Arena on November 17, which will also see performances from the likes of Mabel, Mark Ronson, Anne-Marie, Tom Walker, Zara Larsson and Jonas Blue.
Directioners will be hoping the pair reunite on stage together for the first time since the boyband went on an indefinite hiatus in 2015.
Meanwhile, Hits Live is also coming to Liverpool and Birmingham on November 15 and November 16, respectively.
Hits Radio Breakfast's Fleur East ,Greg Burns and James Barr will host the concerts with all the backstage gossip and exclusive interviews provided by presenter Jordan Lee.
Fleur said: ''Having had many of these brilliant artists on our Breakfast Show over the last few weeks, I'm so hyped to be able to bring them all together over one incredible weekend for Hits Radio listeners. Providing the biggest hits, we have the artists and the locations, now we just need you!''
Tickets for all events are on sale now, from £28 plus booking fees, www.hitsradio.co.uk.
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