The two veteran stars were part of the Brat Pack generation of actors who rose to fame together in the 1980s, and they played young lovers in the films Pretty in Pink and Fresh Horses.
Now Andrew's son Sam is following in his father's career footsteps and he will make his movie debut in All These Small Moments, which will star Molly as the 15-year-old's onscreen mum, reports People.com.
"My son is doing his first movie now, and his screen mum is of course Molly Ringwald!" he laughed on SiriusXM radio show The MOMS. "(He) just auditioned for this movie and he was hired and it turned out that his mother was going to be Molly Ringwald!"
Andrew revealed his old pal emailed him after filming began and gushed about how similar the father-and-son are.
He continued, "She emailed me on the first day and she said, 'Your son just did a scene and when he walked away, it was just like watching you walk away from me 30 years ago.'"
Sam isn't the only MCCarthy member to pursue a career in the limelight - Andrew's daughter Willow, 10, recently made her Broadway debut in Matilda the Musical.
"God help me!" he quipped. "Both my children decide they want to be actors."
Sam is Andrew's only child with his college sweetheart Carol Schneider, while the 54-year-old shares Willow and three-year-old Rowan with his second wife Dolores Rice.
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