The former Culture Club frontman covered Dusty Springfield's hit Son of a Preacher Man in a nod to Tarantino's movie Pulp Fiction, which featured the track in a key scene.
Boy George also entertained the star-studded audience with his tracks including Karma Chameleon and Do You Really Want to Hurt Me.
Tarantino paid tribute to Los Angeles in his acceptance speech, crediting the city with offering him his big break, adding, "I love to talk, and I love to talk about movies... I don't like to talk about my movies."
Other gala attendees included Leonardo DiCaprio, Jamie Foxx, Christoph Waltz, Harvey Weinstein, Jennifer Lopez, Kate Beckinsale, Kanye West and Kim Kardashian.