The band was performing at the Brixton Academy to celebrate the 20th anniversary of their self-titled debut album, when Manson began to worry she would expose herself onstage in front of family and friends, so she stopped the show to get help.
"I need to go somewhere really weird," she said. "I need someone to go and get me some underpants. I've got a wind machine working, my family are here tonight and I got distracted and forgot to put on my underpants. Bear with me... I bet this never f**king happens to Beyonce."
The band played a short musical interlude while Manson went off stage to put her underpants on, and the set continued without a hitch.