George Clooney's new one minute tequila ad will feature the movie hunk in bed with best pal and business partner Rande Gerber's supermodel wife Cindy Crawford.

The It Could Happen... commercial for Clooney and Gerber's beverage brand Casamigos Tequila also features Crawford in bed with the actor's girlfriend Stacy Keibler and the Ocean's Eleven star cuddling up to Gerber.

The footage suggests each couple is sleeping off a heavy night of alcohol as they're discovered first by Gerber, then Clooney and then by Crawford and Keibler.

The movie star celebrated the launch of his tequila on Wednesday night (09Jan13) in Las Vegas by playing bartender to press and invited guests at Encore hotel nightspot Andrea's.

The tipple has been seven years in the making and came about when Clooney and Gerber decided to enter the liquor business as they built adjacent properties in Mexico.