The veteran actresses play two women who become friends after their husbands 'come out' as gay men, and leave them for each other, and in one scenes, Tomlin's character offers Fonda's a muscle relaxer with tea mixed with peyote.

As neither of the stars had experienced a peyote high, they opted to try the hallucinogenic for research.

Tomlin says, "We went on a trial peyote trip.

"It's just a hallucinogenic, it's very spiritual. The plants started wavering, it's a bit like acid, but more extreme. Things move, you see the oneness of the universe..."