The pop veteran hired the comedienne to kick off her three Rebel Heart shows in the Big Apple, and Schumer won a slew of positive reviews for her opening stand-up performance at Madison Square Garden.

Madonna later brought Schumer back onstage to take part in a racy segment during a rendition of her track Unapologetic B**ch, and the singer pretended to spank her and kick her butt, while also simulating a sex act.

Schumer also showed off her dance skills by performing a 'twerking' routine.

She later shared pictures of her big night on her account, adding in a caption, "I am dead... Madonna", while the pop superstar also added a snap and wrote, "Love You Amy!... B**ch You are in my gang! Thank. You!!..."