The 43-year-old singer - who has written a number of songs about illegal substances, including 'Dope Show' - claims to have ''no health problems'' thanks to years of consuming alcohol and taking drugs.
He said: ''My body is a place where drugs and alcohol have made germs afraid to live. I have no health problems to speak of, touch wood.''
Marilyn is currently dating fashion model and photographer Lindsay Usich, and he is keen to start a family with her so that their little one can ''breathe profanity''.
He explained: ''My girlfriend Lindsay's twin just had a baby and I've started to think that maybe I wouldn't mind passing my demented genius on to some small thing who can set fire and breathe profanity.''
Marilyn admits he is still on ''good terms'' with his ex-wife Dita Von Teese - who he tied the knot with in November 2005 before the pair divorced in 2007 - despite her seeming ''p***ed'' at him during a recent meeting.
He added to the Observer Magazine: ''I'm on good terms with my ex-wife, but I saw her recently at the Met Bar in London and I think there's a part of her that's still p***ed at me.
''I am drawn to women who are independent and creative, which is problematic because it's a struggle, a competition of careers. There's jealousy. And if you don't want to be known as Marilyn Manson's girlfriend, why would you be it?
''I'm not some sort of sexual deviant. I think I would laugh nervously in the face of a threesome. I'm shy. I'm the kind of person who turns The Lights out.''