The Sleepless in Seattle star stepped behind the camera to shoot Ithaca, her first movie as a director, and it is due to hit cinemas in the U.S. in December (15).

Ryan is now using the career milestone to help raise cash for the Los Angeles branch of the Leukemia & Lymphoma Society by selling a signed and personalised copy of the Ithaca script in an auction on

Describing the item, the website owners note, "Own this one-of-a-kind Ithaca screenplay, signed by Meg Ryan! Due to be released later this year, Ithaca is Meg Ryan's directorial debut film. She also stars in the film, alongside Tom Hanks and Sam Shepard. This is currently the only Meg Ryan autographed Ithaca script out there. Don't miss your chance to own a piece of Hollywood history."

The top bid stood at $150 (£93) as WENN went to press, and the auction is due to end on Friday (29May15).