The unlikely couple will play lifelong best friends on vacation in The Layover.

Michele took to Twitter to break the news to fans on Thursday (26Mar15), writing, "So excited to be working with the amazing @WilliamHMACy & the gorgeous @KateUpton on our new film #TheLayover this spring!!!

"We've already started rehearsals and have been having the best time!!! This is going to be a fun one!!!"

MACy, who will direct the film, confirmed the news with a tweet, adding, "Guess it's not a secret anymore. I'm directing a comedy and I could not be more thrilled with the lead actors!"