The rock icon passed away at his home in Suffolk, England at the age of 71 after a battle with liver disease and Clapton, who formed Cream with Bruce in 1966, has taken to Facebook.com to remember him.
He writes, "It is with great sadness that we learned that Jack Bruce had passed away... He was a great musician and composer, and a tremendous inspiration to me."
Kiss frontman Paul Stanley, Beatles legend Ringo Starr and former Guns N' Roses star Slash are among many others who have also offered their condolences.
Clapton, Bruce and their bandmate Ginger Baker split in 1968 but regrouped In 1993 when they were inducted into the Rock and Roll Hall of Fame. The trio officially reunited for a series of shows in London and New York in 2005, but fans' hopes of future concerts were dashed as the trio fell out publicly.
Bruce later revealed the group had considered performing at the tribute concert for music mogul Ahmet Ertegun in 2007, but opted out when the gig became "overly commercial", and in a Bbc interview in April, 2010, the bass player announced, "Cream is over".
Baker has also released a statement after hearing about the passing of his former bandmate. It reads: "I am very sad to learn of the loss of a fine man, Jack Bruce... My thoughts & wishes are with his family at this difficult time."
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